"Even when you are creating documents for a CMYK offset press, the best practice is to work in an large gamut RGB editing space (with Proof Setup on and set to document CMYK), and then make the conversion to CMYK later in the workflow when the actual press profile is known. A color managed conversion to the final press profile can happen in Photoshop, but the same conversion can happen on an export to PDF from the page layout, or from the printer’s RIP.
"There are a number of problems editing in a CMYK space. The black generation, gray component replacement, gray balance, and total ink amount required by specific press conditions are built into a CMYK profile—all of which could be ruined with color corrections after the conversion to CMYK. Also, layer adjustments and Blending modes don’t work well in CMYK—it can be easy to exceed total ink limits when blending colors."
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